Automated nucleic acid extraction
The Trilobot’s enclosed system includes a HEPA filter and completely automates DNA and RNA purification.
Automating nucleic acid extraction on Trilobots
A manual extraction means pipetting lysis buffer, wash steps, and elution by hand across every sample, with RNA degrading the moment it's exposed to an open bench. The Trilobot runs the full sequence—lyse, bind, wash, elute—inside an enclosed system fitted with a HEPA filter, so DNA and RNA come off the deck with less handling and less risk of degradation between steps. The Trilobot is built to automate your nucleic acid extraction workflow, scale throughput, and increase walkaway time.

Scale extraction at your own pace
Every lab automates at a different pace. Start with one Trilobot on your extraction workflow, then add machines and connect downstream instruments as your sample volume grows.
What is nucleic acid extraction?
Nucleic acid extraction is the process of isolating DNA or RNA from a biological sample so it's clean enough for downstream work like PCR, sequencing, or cloning. It's one of the most repeated protocols in a molecular biology lab, run by academic researchers, diagnostics teams, and biotech labs processing anywhere from a handful of samples to hundreds a day.
Challenges of manual nucleic acid extraction
Benefits of automating nucleic acid extraction with Trilobio
Built-In Reliability
Consistent liquid handling at every step means data quality reflects your biology, not variability introduced at the bench.
Full Walkaway
Load your samples and walk away. Trilobot runs multi-step protocols unattended—no babysitting required.
More Data Points Per Plate
Because the system is integratable with your assay setup, every well can run a different condition instead of duplicating one, giving you more usable data out of each plate.
Lower Contamination Risk
Every Trilobiot is enclosed and HEPA-filtered, keeping your samples sterile from start to finish.
End-to-End on One Platform
More of your workflow runs on one platform, so you spend less time managing instrument handoffs and more time on the science.
Run-to-Run Reproducibility
Every sample follows the same protocol to the same specification—no operator variation between technicians or across runs.
Flexible by Design
Swap tools, scale volumes, change formats—the Trilobot adapts to your workflow, not the other way around.
Starts at $25k/year
Full lab automation starting at $25k/year—less than most labs spend on a single liquid handler.
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Frequently asked
questions
Explore how nucleic acid extraction automation works, what makes it different with the Trilobot, and how Trilobio transforms everyday biology workflows.
Automating nucleic acid extraction and DNA & RNA purification starts at $25k/year with Trilobio.
DNA purification isolates DNA from a sample while removing proteins, RNA, salts, and other contaminants that would interfere with downstream steps like PCR or sequencing.
RNA purification isolates RNA from a sample while removing DNA, proteins, and other contaminants. It's more delicate than DNA purification since RNA degrades quickly once cells are lysed, so the Trilobot runs the extraction in an enclosed, HEPA-filtered system to protect RNA integrity throughout.
Many automated extraction systems are built for high-budget labs. The Trilobot handles a wide range of input types in one enclosed, HEPA-filtered system starting at only $25k/year, and it scales from a single machine to a connected multi-instrument setup as your throughput (and lab) grows.
The Trilobot lyses your samples, then uses an on-deck magnet to bind DNA or RNA to magnetic beads on labware you define in Trilobio OS, washes away contaminants, and elutes purified nucleic acid without a technician at the bench. You can also connect additional steps to the same run, like a plate reader for QC or a thermal cycler for downstream PCR, so extraction isn't an isolated step in your workflow.