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Automated nucleic acid extraction

The Trilobot’s enclosed system includes a HEPA filter and completely automates DNA and RNA purification.

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Automating nucleic acid extraction on Trilobots

A manual extraction means pipetting lysis buffer, wash steps, and elution by hand across every sample, with RNA degrading the moment it's exposed to an open bench. The Trilobot runs the full sequence—lyse, bind, wash, elute—inside an enclosed system fitted with a HEPA filter, so DNA and RNA come off the deck with less handling and less risk of degradation between steps. The Trilobot is built to automate your nucleic acid extraction workflow, scale throughput, and increase walkaway time.

Workflow diagram of how automated nucleic acid extraction and RNA and DNA purification works

Scale extraction at your own pace

Every lab automates at a different pace. Start with one Trilobot on your extraction workflow, then add machines and connect downstream instruments as your sample volume grows.

One Trilobot Two Trilobots Three Trilobots
Best for Targeted solution for nucleic acid extraction and purification Independent workstations for DNA and RNA process isolation Labs optimizing for high-throughput operations
What it automates ~100% of your extraction workflow ~100% of your extraction workflow ~100% of your extraction, QC, and NGS workflows
Integrated equipment On-deck temperature module (optional) On-deck temperature module (optional) 1-3 frames with multiple instruments
Throughput 700+ samples/day 1500+ samples/day 1500+ samples/day
Walkaway time* 3 hours 3 hours 3+ hours
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Based on a 3-hour workflow

At $25k/year, the Trilobot pays for itself

Traditional lab automation systems can run into six figures. Learn how you can automate nucleic acid extraction in your lab at a fraction of the cost.

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What is nucleic acid extraction?

Nucleic acid extraction is the process of isolating DNA or RNA from a biological sample so it's clean enough for downstream work like PCR, sequencing, or cloning. It's one of the most repeated protocols in a molecular biology lab, run by academic researchers, diagnostics teams, and biotech labs processing anywhere from a handful of samples to hundreds a day.

Challenges

Challenges of manual nucleic acid extraction

Waiting Between Steps

Between timed incubations, washes, and spin steps, there's plenty of downtime—but you still can't leave the bench. You're present for the whole run, productive for only part of it.

Equipment Babysitting

Multi-step prep requires constant attention across timed incubations, reagent additions, and plate transfers, keeping a technician tethered to the bench for most of the run.

Low Throughput

Preparing samples manually can consume an entire day of technician time.

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Poor Sample-to-Sample Consistency

Variability between technicians and across runs adds noise to your data.

Opportunity Cost

Sample prep isn’t where the innovation happens, but it's often where scientists spend their time.

benefits

Benefits of automating nucleic acid extraction with Trilobio

Built-In Reliability

Consistent liquid handling at every step means data quality reflects your biology, not variability introduced at the bench.

Full Walkaway

Load your samples and walk away. Trilobot runs multi-step protocols unattended—no babysitting required.

More Data Points Per Plate

Because the system is integratable with your assay setup, every well can run a different condition instead of duplicating one, giving you more usable data out of each plate.

Lower Contamination Risk

Every Trilobiot is enclosed and HEPA-filtered, keeping your samples sterile from start to finish.

End-to-End on One Platform

More of your workflow runs on one platform, so you spend less time managing instrument handoffs and more time on the science.

Run-to-Run Reproducibility

Every sample follows the same protocol to the same specification—no operator variation between technicians or across runs.

Flexible by Design

Swap tools, scale volumes, change formats—the Trilobot adapts to your workflow, not the other way around.

Starts at $25k/year

Full lab automation starting at $25k/year—less than most labs spend on a single liquid handler.

Ready to automate nucleic acid extraction in your lab?

Tell us about your extraction workflow, and we'll show you exactly how the Trilobot fits in.
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Close-up of a black mechanical robotic arm component against a dark background.

Frequently asked
questions

Explore how nucleic acid extraction automation works, what makes it different with the Trilobot, and how Trilobio transforms everyday biology workflows.

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How much does it cost to automate nucleic acid extraction?

Automating nucleic acid extraction and DNA & RNA purification starts at $25k/year with Trilobio.

What is DNA purification?

DNA purification isolates DNA from a sample while removing proteins, RNA, salts, and other contaminants that would interfere with downstream steps like PCR or sequencing.

What is RNA purification?

RNA purification isolates RNA from a sample while removing DNA, proteins, and other contaminants. It's more delicate than DNA purification since RNA degrades quickly once cells are lysed, so the Trilobot runs the extraction in an enclosed, HEPA-filtered system to protect RNA integrity throughout.

How does the Trilobot compare to other automated nucleic acid extraction systems?

Many automated extraction systems are built for high-budget labs. The Trilobot handles a wide range of input types in one enclosed, HEPA-filtered system starting at only $25k/year, and it scales from a single machine to a connected multi-instrument setup as your throughput (and lab) grows.

How does Trilobio automate nucleic acid extraction?

The Trilobot lyses your samples, then uses an on-deck magnet to bind DNA or RNA to magnetic beads on labware you define in Trilobio OS, washes away contaminants, and elutes purified nucleic acid without a technician at the bench. You can also connect additional steps to the same run, like a plate reader for QC or a thermal cycler for downstream PCR, so extraction isn't an isolated step in your workflow.

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